Objective：To observe the effects of the combination of calming foot bath and hemodialysis on sleep quality,dialysis quality,hypersensitive c-reactive protein(hs-CRP),interleukin-6 (IL-6)and tumor necrosis factor alpha (TNF-α)in patients with sleep disorders. Methods：According to the random number table method,60 patients with maintenance hemodialysis and sleep disorder were divided into study group and control group,30 cases each. The control group was given psychological nursing care and basic blood purification treatment.The team on the basis of psychological nursing,3 times per week Hemodiafiltration (HDF) treatment and calming foot bath. Both groups were treated for 2 months. The PSQI score,K-T/V score,hs-CRP,IL-6 and TNF-α of the two groups before and after intervention were compared. Results：(1)Before intervention,the PSQI score,K-T/V score ,hs-CRP,IL-6 and TNF-α of the two groups of patients were compared,and the differences were not statistically significant(P＞0.05)；(2)After intervention,K-T/V score of patients in both groups was higher than that before intervention(P＜0.05)；the PSQI score ,hs-CRP,IL-6 and TNF-α of patients in both groups were lower than that before intervention(P＜0.05)；(3)After intervention,K-T/V score of the study group was higher than that of the control group (P＜0.05)；the PSQI score ,hs-CRP,IL-6 and TNF-α of the study group were lower than that of the control group(P＜0.05). Conclusion：The combination of calming foot bath and hemodiafiltration can improve the sleep quality,dialysis quality and immune function of hemodialysis patients.