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中药浸泡在阿帕替尼致手足综合症防治中的临床应用
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南京医科大学附属常州市第二人民医院

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常州市科技支撑社会发展项目(CE20165024)


Effect of Chinese herbal immersion in prevention and treatment of apatinib induced hand-foot syndrome
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Department of Radiotherapy,the Changzhou Second People’S Hospital,Affiliated Hospital of Nanjing Medical University

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    摘要:

    目的 探讨中药浸泡在阿帕替尼致手足综合症防治中的临床应用价值。方法 2016年1月至2017年12月间我科收治的口服阿帕替尼的食管癌和肠癌患者157例随机分为两组,中药组72例每日两次采用中药浸泡,对照组85例采用温水浸泡。比较两种不同浸泡方法对手足综合症发生率和严重程度的影响。结果 全组患者Ⅰ、Ⅱ和Ⅲ级手足综合症发生率分别为12.7%、10.2%和6.4%。中药组和对照组Ⅰ、Ⅱ、Ⅲ级手足综合症发生率分别为8.3%、6.9%、4.2%和16.5%、11.0%、10.1%,对照组各级手足综合征发生率均高于中药组(P=0.015)。结论 中药浸泡能降低阿帕替尼引起的手足综合症发生率及严重程度,值得在临床工作中推广应用。

    Abstract:

    Objective ToSobserveStheSeffectSof Chinese herbal immersion in prevention and treatment of hand-foot syndrome caused by apatinib. Methods From Jan 2016 to Dec 2017, 157 patients with esophageal carcinoma and intestinal carcinoma treated with apatinib were randomly divided into Chinese medicine group (n=72), in which their hands and feet were immersed in Chinese herbal liquid twice a day; and control group (n=85), in which their hands and feet were immersed in warm water twice a day. Then we compared the incidence and severity of hand-foot syndrome between the groups. Results Among all the patients the incidence of I, II and III degree hand-foot syndrome were 12.7%, 10.2% and 6.4%, respectively. The rates of I, II, III degree hand-foot syndrome in Chinese medicine group and control group were 8.3%, 6.9%, 4.2% and 16.5%, 11.0%, 10.1%, respectively, and the rate in control group was higher than that in Chinese medicine group(P=0.015). Conclusion Chinese herbal immersion could reduce the incidence and severity of hand-foot syndrome for cancer patients treated with apatinib, which was valuable to be applied in clinics.

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徐玲,李华芬,汪建林,薛敏芬,张维,屈冶.中药浸泡在阿帕替尼致手足综合症防治中的临床应用[OL]. NursRxiv,2020,
DOI:10.12209/issn2708-3845.20200630001

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  • 收稿日期:2020-06-30
  • 最后修改日期:2020-06-30
  • 录用日期:2020-06-30
  • 在线发布日期: 2020-06-30
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