The Macao government attaches great importance to the anti-epidemic measures of the novel coronavirus pneumonia (coronavirus disease 2019, COVID-19). It had taken steps to deal with COVID-19 even before the ?rst case was detected, and formulated stricter rules after the occurrence of several imported cases. These measures were to cut out the link of the epidemiological triangle, including: 1) controlling the infection source. Macao government quickly established a multi-sectoral response coordination team to isolate potential cases and detect cases early by closely tracing arrivals from outside Macao; 2) stopping the route of transmission. The government implemented a mask supply plan, shut down entertainment venues during the peak of the epidemic, and used public media to disseminate anti-COVID-19 information, such as maintaining social distance and frequent hand wash; 3) protecting susceptible people. The government took a series of measures to protect minors, the elderly in institutions and workers in medical institutions from infection. While Macao has done a better job in ?ghting COVID-19 than some of the neighboring regions, it is not a perfect performer. Suggestions for addressing weaknesses Macao has shown in the ?ght are o?ered in the article.