Objective To evaluate the health economic effects of standardized nursing program in bedridden patients with stroke. Methods From September 2016 to July 2017, we carried out standardized nursing training of four common complications (pressure ulcers, lower extremity deep venous thrombosis, pulmonary infections and urinary tract infections) for the included nurses in departments from 25 hospitals at different levels in six provinces of China. The training included risk assessment and preventive nursing which were applied in bedridden patients. From November 2015 to June 2016, we investigated 4 118 bedridden patients in control group. From November 2016 to July 2017, we investigated 3 940 bedridden patients in experimental patients. Bedridden inpatients with stroke of control group adopted routine nursing, while patients of experimental group were treated with the standardized nursing based on "Nursing Standard for Common Complications of Bedridden Patients". We compared the hospital stay, time in bed, incidences of bed complications, economic burden of disease of patients between two groups, and analyzed the incremental cost-effectiveness ratio. Results? Being compared with those in control group, the hospital stay [(16.83±14.68)d vs. (16.28±14.58)d] and time in bed [(25.31±232.60)d vs. (23.93±166.64)d] of patients in experimental group shortened with statistical differences (t=2.59, 2.27;P＜ 0.05); the incidences of pressure ulcers, pulmonary infections and urinary tract infections reduced in varying degrees; the direct and indirect economic burden as well as the total economic burden of disease decreased with statistical differences (P＜0.05). The incremental cost-effectiveness ratio was 13 658.14. Conclusions The standardized nursing can reduce the incidences of bed complications and its economic burden of stroke patients which has cost-effectiveness and is worthy of being widely used in clinical application.