Objective To evaluate the effect of FOCUS-PDCA model in hypoglyeenfia management during hemodialysis in patients with diabetic nephropathy. Methods Totally 97 patients with diabetic nephropathy were divided into two groups. Patients in the control group received traditional hypoglycemia management,while FOCUS- PDCA model was implemented in the experimental group in hypoglycemia management,including reducing insulin dosage before hemodialysis,injecting 50% glucose and taking hyperglycemia food during hemodialysis,enhaneing the monitoring of blood glucose and heahh education. Results The frequency of hypoglycemia in the experimental group was significantly lower than that in the control group(P〈0.01),and no hypoglycemia-induced accident event occulted. Conclusion The application of FOCUS-PDCA model in the hypoglycemia management of patients with diabetic nephropathy can reduced the incidence of hypoglycemia during hemodialysis. It deserves to be widely used in clinical practice to improve the patients＇ quality of life.