This paper analyzed the clinical data of 5 patients with skin rash caused by pegylated?interferon?α-2a?combined?with?ribavirin?therapy of chronic viral hepatitis C. According to the clinical symptoms, patients were given internal administration of Chinese herbal medicine decoction combined with external wash of Chinese herbal medicine decoction. Comprehensive interventions including skin care, infection prevention, nutrition support and psychological nursing were carried out during the treatment.