Objective To investigate the effect of evidence-based scene simulation combined with problem-based learning in clinical teaching of critical care for nursing students. Methods Totally 65 nursing students were randomly divided into the study group （n=33）and the control group（n=32）. Conventional teaching model were adopted in clinical teaching of critical care for nursing students in the control group, and evidence-based scene simulation combined with problem-based learning were used in clinical teaching of critical care for nursing students in the study group. The theoretical examination, clinical practice skills and student satisfaction with clinical teaching were measured and compared between two groups. Results Scores of theoretical examination, clinical practice assessment and satisfaction evaluation in the study group were higher than those in the control group (P＜0.05, respectively). Conclusion The evidence-based simulation combined with problem-based learning is effective to arouse students’ motivation and interest in learning English, deepen the understanding of theoretical knowledge, improve the independent problem-solving ability and enhance the clinical practice skills.