Objective To investigate the effect of humanistic care in nursing management of patients with liver disease under the under the regular epidemic prevention and control of COVID-19. Methods According to the sequence of hospital admission, totally 82 patients with liver disease were divided into two groups: 41 cases in control group and 41 cases in the observation group. Patients in both control and observation group received routine care during the treatment, and those in the observation group were given humanistic nursing interventions. The Patient acceptance of humanistic care and satisfaction with nursing service were measured. Results? The satisfaction rate in the observation group was higher than that in the control group (P＜0.01). The Self-rating Anxiety Scale (SAS) score decreased in both groups after intervention, and SAS score in the in the observation group was lower than that in the control group (P＜0.01). Conclusion? Under the regular epidemic prevention and control of COVID-19, implementation of humanistic nursing intervention based on the hospital infection management is potentially effective in relieve anxiety and improving satisfaction degree of patients with liver disease.