To summarize the comprehensive nursing experience in a case of typhoid fever complicated with intestinal bleeding. Based on the nursing risk assessment, comprehensive nursing interventions including guidelines on rest and exercise programs, disinfection protection, psychological nursing, observation and nursing of high fever, observation and nursing of diarrhea, diet nursing and continuous nursing were carried out. omprehensive nursing interventions were implemented to relieve the symptoms of diarrhea, relieve the pain of the patients, shorten the course of the disease, and prevent cross-infection of the disease.