This paper summarizes the nursing experience of a patient with chemotherapy-associated oral mucositis treated with Chinese herbal mouthwash combined with moxibustion. Firstly, risk assessment and grading were performed; then the herbal mouthwash combined with moxibustion treatment was combined with comprehensive nursing interventions such as personalized diet regulation, emotional care, health guidance and continuation care, in order to reduce the patient''s ulcer pain, accelerate ulcer healing, improve his quality of life and enhance his treatment compliance.