Objective To explore the application effect of quality control circle (QCC) activities in improving the implementation rate of deep vein thrombosis (DVT) prevention in patients undergoing urological surgery. Methods From July 2020 to December 2020, 125 cases of urology surgery patients with lack of management of DVT were investigated. The causes were analyzed according to the investigation results, and the improvement plan was established and implemented based on evidence. The implementation condition of DVT prevention in another 125 cases of urology surgery patients was evaluated after QCC activities. Results The implementation rate of DVT prevention increased from 62.40% before implementation of QCC activities to 97.60％ after implementation of QCC activities, with a significant difference (P<0.05). Conclusion Application of QCC management tool can improve the management standard of DVT prevention in patients undergoing urological surgery and effectively reduce the incidence of DVT.