Objective To investigate the effect of continuous nursing intervention on medication safety in elderly patients with chronic diseases. Methods Totally 100 elderly patients with chronic diseases were randomly divided into the observation group and control group, with 100 cases in each group. Patient in the control group received routine discharge guidance and follow-up, and those in the observation group were given continuous nursing intervention. The medication safety and rehospitalization situation were analyzed at 6 month after discharge form hospital. A questionnaire survey was conducted to measure the compliance and satisfaction of patients after discharge form hospital. Results The rates of unauthorized increase, decrease, withdrawal and missing of medication in the observation group were lower than those in the control group（P＜0.05, respectively）. The re-hospitalization rate in the observation group was lower than that in the control group (4.00% vs. 18.00%, P＜0.05). The scores of satisfaction evaluation about dietary, rehabilitation exercise, hospital reexamination and hygiene in the observation group were higher than those in the control group（P＜0.01）. The satisfaction rate in the observation group was higher than those in the control group（P＜0.05）. Conclusion The continuous nursing intervention is potentially effective to improve the medication safety and treatment compliance after discharge from hospital in elderly patients with chronic diseases.