This paper summarized the nursing measures for a patient with chronic obstructive pulmonary disease complicated with type II respiratory failure treated by sequential non-invasive positive pressure ventilation via nasal high-flow oxygen therapy. Nursing interventions were carried out in the following ways: non-invasive positive pressure ventilation, medication nursing, enteral nutrition support, pipeline maintenance, skin care and psychological nursing and other issues. Efforts were made to improve the respiratory failure status and various vital signs, control of carbon dioxide retention and reduce the occurrence of complications. By providing patients with a constant, adjustable, high-speed breathing gas mixture formed from air and oxygen, it was aimed to crush the gas left in the nasal cavity, oral cavity and pharynx, and significantly reduce the amount of carbon dioxide inhaled during the next inhalation. The application of sequential treatment with transnasal high-flow oxygen therapy has achieved positive therapeutic results in patients with hypoxic respiratory failure.