Objective To systematically evaluate the clinical effect of acupoint application in the treatment of postoperative pain of mixed. Methods The CNKI, VIP, Wanfang Data, CBM and PubMed databases were searched by computer. Randomized controlled trials (RCTs) on the efficacy of acupoint application in the treatment of postoperative pain of mixed were included. The?retrieval?time?was?from?the?establishment?of?each?database?to December 2021. A literature screening, quality evaluation and data extraction were independently conducted by two reviewers in accordance with the inclusion and exclusion criteria. A Meta analysis was then carried out using RevMan 5.3 software. Results In total, 6 RCTs involving 532 patients were included in the meta-analysis. The Meta analysis showed that?effective rate of pain control in the study group was higher than that in the control group (RR = 1.03，95%CI[1.02, 1.15]，P = 0.0001). The Visual Analogue Scale of pain in the in the study group was lower than that in the control group at 1 day(MD =?1.32，95%CI[?2.33, ?0.31], P = 0.01), 3 days (MD = ?1.64， 93% CI[?2.51, ?0.76]，P=0.002) and 5 days (MD = ?1.32, 95%CI[?1.89, ?0.75], P < 0.00001) after surgery. Conclusion The implementation of acupoint application could relieve the postoperative pain of patients undergoing surgical treatment for mixed hemorrhoids. However, given the low quality of included research methodology and small sample size, more efforts should be paid on large sample size and multi-centered clinical randomized control trails, especially studies concerning the long-term intervention efficacy.