Abstract：Evidence-based summaries or synthesis can support evidence-informed practice, by presenting high-quality health research evidence in COVID-19 outbreak response. Given the COVID-19 outbreak, the limitations of timeliness, quantity and quality of evidence may bring challenges to the summary and synthesis writing of evidence-based interventions. This paper briefly discussed the potential problems, as well as their corresponding measures, in the synthesis of evidence-based nursing interventions in the COVID-19 outbreak response.