Objective To form a maternal and infant nursing teaching plan based on" high-level, innovative and challenging" and improve overall teaching quality of obstetrics and gynecology nursing. Methods Taking the curriculum of Puerperium Management as an example, guided by the core competence of midwives and " high-level, innovative and challenging", the research group analyzed the nursing teaching documents and collected postpartum maternal-infants nursing-related literature, guidelines and evidence-based recommendations issued by authoritative organizations at home and abroad. After two rounds discussion, a teaching design was established. Results The teaching content of puerperium management is divided into 2 modules. The first teaching content is postpartum women's care, including the physical and mental changes of puerperium women and related nursing management. The length of time in teaching a theoretical class is 2 hours, and learning objectives are nursing in different periods of postpartum, the identification and assessment of abnormal problems and the multiple attributes of confinement nursing. The second teaching content is breastfeeding, including breastfeeding preparation and consultation, early promotion of breastfeeding strategies, nursing of common breastfeeding problems. The length of time in teaching a practice class is 4 hours, and learning objectives focus on breastfeeding problem assessment and resolution, non-violent communication skills and evidence-based thinking training. The learning process includes self-directed learning, case discussions, and flipped classrooms. The evaluation methods include knowledge assessment, oral presentation, breastfeeding simulation consultation and guidance, and review assignments. Conclusion Fully excavate non-high-risk maternal and infant nursing teaching advanced, high-level and challenging degree, highlight thinking and ability training, which has reference significance for obstetrics and gynecology nursing teaching.